Thermo Fisher Nova 200 Nanolab SEM/FIB


  • Surface and cross section imaging (topology, chemistry, phase contrast)
  • Orientation imaging
  • 3D imaging
  • TEM and APT specimen preparation


Allen Hunter


Room G023


Publications, presentations, and posters resulting from work on this instrument should state: “The authors acknowledge the financial support of the University of Michigan College of Engineering and NSF grant #DMR-0320740, and technical support from the Michigan Center for Materials Characterization.


  • Accelerating Voltage
    • Electrons: 0.2 to 30 kV
    • Ions: Up to 30kV
  • Electron Filament: Schottky Field Emitter
  • Detectors
    • Electron Imaging – Everhart-Thornley Detector (ETD)
    • Electron Imaging – Through-the-lens Detector (TLD)
    • EDAX XEDS system integrated into the Support PC
  • SEM Resolution
    • 1.1 nm @ 15 kV (TLD-SE)
    • 2.5 nm @ 1 kV (TLD-SE)
    • 3.5 nm @ 500 V (TLD-SE)
  • Ion Resolution: 7 nm @ 30 kV @ 1 pA
  • Gas Injectors
    • Platinum
    • XeF2
  • Micromanipulator
    • Kleindiek Nanotechnik MM3A
    • Omniprobe Autoprobe 200
    • Bigelow Micromanipulator
  • Included Software
    • AutoFIB, AutoTEM, Slice and View and XtDoc


  1. Multifactorial Engineering of Biomimetic Membranes for Batteries with Multiple High-Performance Parameters, M. Wang, A.E. Emre, J-Y. Kim, Y. Huang, L. Liu, V. Cecen, Y. Huang, N.A. Kotov, Nature Communications, 13, 278, 2022
  2. Highly Sensitive and Quantitative Biodetection with Lipid-Polymer Hybrid Nanoparticles Having Organic Room-Temperature Phosphorescence, D.H. Kang, Y. Zeng, M. Tewari, J. Kim, Biosensors and Bioelectronics, 199, 113889, 2022
  3. Non-Fullerene Acceptor Organic Photovoltaics with Intrinsic Operational Lifetimes over 30 years, Y. Li, X. Huang, K. Ding, H.K.M Sheriff Jr., L. Ye, H. Liu, C-Z. Li, H. Ade, S.R. Forrest, Nature Communications, 12, 5419, 2021
  4. Compositional and Morphological Properties of Platinum-Iridium Electrodeposited on Carbon Fiber Microelectrodes, E. della Valle, E.J. Welle, C.A. Chestek, J.D. Weiland, Journal of Neural Engineering, 18(5), 2021
  5. Structural Analysis of Nanoscale Network Materials using Graph Theory, D.A. Vecchio, S.H. Mahler, M.D. Hammig, N.A. Kotov, ACS Nano, 15(8), 12847-12859, 2021
  6. Geometric Optimization of Bismuth Vanadate Core–Shell Nanowire Photoanodes using Atomic Layer Deposition, A.R. Bielinski, A.J. Gayle, S. Lee, N.P. Dasgupta, ACS Applied Materials & Interfaces, 2021
  7. A Facile Process to Fabricate Phosphorus/Carbon Xerogel Composite as Anode for Sodium Ion Batteries, C. Deng, W. Lu, Journal of the Electrochemical Society, 168, 080529, 2021
  8. Sub-100 nm high spatial frequency periodic structures driven by femtosecond laser induced desorption in GaAs, A. Sarracino, A.R. Ansari, B. Torralva, S. Yalisove, Applied Physics Letters, 119, 019902, 2021
  9. Precipitation in Proton-and Ion-Irradiated Alloy 625 Plus, L-J. Yu, E.A. Marquis, Journal of Nuclear Materials, 153040, 2021 
  10. Reversal of Carbonate-Silicate Cation Exchange in Cold Slabs in Earth’s Lower Mantle, M. Lv, S.M. Dorfman, J. Badro, S. Borensztajn, E. Greenberg, V.B. Prakapenka, Nature Communications, 12, 1712, 2021
  11. The Role of Co-injected Helium on Swelling and Cavity Evolution at High Damage Levels in Ferritic-Martensitic Steels, D. Woodley, S. Taller, Z. Jiao, K. Sun, G.S. Was,  Journal of Nuclear Materials, 550, 152912, 2021
  12. Photocatalytic Hedgehog Particles for High Ionic Strength Environments, D.G. Montjoy, H. Hou, J.H. Bahng, A. Eskafi, R. Jiang, N.A. Kotov, ACS Nano, 15(3), 2021, 4226-4234
  13. On‐Chip Biogenesis of Circulating NK Cell‐Derived Exosomes in Non‐Small Cell Lung Cancer Exhibits Antitumoral Activity, Y-T. Kang, Z. Niu, T. Hadlock, E. Purcell, T-W. Lo, M. Zeinali, S. Owen, V.G. Keshamouni, R. Reddy, N. Ramnath, S. Nagrath, Advanced Science News, 2003747, 2021
  14. Bulk Transport Paths through Defects in Floating Zone and Al Flux Grown SmB6, Y.S. Eo, A. Rakoski, D. Mihaliov, W.T. Fuhrman, S.R. Saha, P.F.S. Rosa, Z. Fisk, M.C. Hatnean, G. Balakrishnan, J.R. Chamorro, S.M. Koohpayeh, T.M. McQueen, B. Kang, M-S. Song, B. Cho, M.S. Fuhrer, J. Paglione, C. Kurdak, Condensed Matter, 2020
  15. Fast Organic Vapor Phase Deposition of Thin Films in Light-Emitting Diodes, B. Qu, K. Ding, S. Hou, S. Morris, M. Shtein, S.R. Forrest, ACS Nano, 14(10), 14157-14163, 2020
  16. Programmable Delivery of Synergistic Cancer Drug Combinations Using Bicompartmental Nanoparticles, J.V. Gregory, D.R. Vogus, A. Barajas, M.A. Cadena, S. Mitragotri, J. Lahann, Advanced Healthcare Materials, 9(21), 2000564, 2020
  17. Omnidispersible Microscale Colloids with Nanoscale Polymeric Spikes, D.G. Montjoy, H. Hou, J.H. Bahng, N.A. Kotov, Chem. Mater., 32(23), 9897-9905, 2020
  18. Dual‐Isolation and Profiling of Circulating Tumor Cells and Cancer Exosomes from Blood Samples with Melanoma Using Immunoaffinity‐Based Microfluidic Interfaces, Y-T. Kang, T. Hadlock, T-W. Lo, E. Purcell, A. Mutukuri, S. Fouladdel, M. De Silva Raguera, H. Fairbairn, V. Murlidhar, A. Durham, S.A. McLean, S. Nagrath, 7, 2001581, Adv. Sci, 7, 2001581, 2020
  19. Understanding Bubble and Void Nucleation in Dual Ion Irradiated T91 Steel using Single Parameter Experiments, S. Taller, G.S. Was, Acta Materialia, 198, 47-60, 2020
  20. Engineered Ovalbumin Nanoparticles for Cancer Immunotherapy, N. Habibi, S. Christau, L.J. Ochyl, Z. Fan, A.H. Najafabadi, M. Kuehnhammer, M. Zhang, M. Helgeson, R. von Klitzing, J.J. Moon, J. Lahann, Advanced Therapeutics, 3(10), 2020
  21. Tumour-Reprogrammed Stromal BCAT1 Fuels Branched-Chain Ketoacid Dependency in Stromal-Rich PDAC Tumours, Z. Zhu, A. Achreja, N. Meurs, O. Animasahun, S. Owen, A. Mittal, P. Parikh, T-W. Lo, J. Franco-Barraza, J. Shi, V. Gunchick, M.H. Sherman, E. Cukierman, A.M. Pickering, A. Maitra, V. Sahai, M.A. Morgan, S. Nagrath, T.S. Lawrence, D. Nagrath, Nature Metabolism, 2, 775-792, 2020
  22. Microstructural Responses of Alloy 625 and Alloy 625 Plus Under Ion and Proton Irradiations, L-J. Yu, E.A. Marquis, JOM, 72(8), 2993-3002, 2020
  23. Plasmonic Nanoparticles Assemblies Templated by Helical Bacteria and Resulting Optical Activity, W. Feng, U. Kadiyala, J. Yan, Y. Wang, V.J. DiRita, J.S. VanEpps, N.A. Kotov, Chirality, 32, 899-906, 2020
  24. Ultra-Small Carbon Fiber Electrode Recording Site Optimization and Improved In Vivo Chronic Recording Yield, E.J. Welle, P.R. Patel, J.E. Woods, A. Petrossians, E. della Valle, A. Vega-Medina, J.M. Richie, D. Cai, J.D. Weiland, C.A. Chestek, Journal of Neural Engineering, 17, 026037, 2020
  25. Self-Assembly of Chiral Nanoparticles into Semiconductor Helices with Tunable Near-Infrared Optical Activity, J. Yan, W. Feng, J-Y. Kim, J. Lu, P. Kumar, Z. Mu, X. Wu, X. Mao, N.A. Kotov, Chem. Mater., 32(1), 476-488, 2020 
  26. Magnetic Frustration Control through Tunable Stereochemically Driven Disorder in Entropy-Stabilized Oxides, P.B. Meisenheimer, L.D. Williams, S.H. Sung, J. Gim, P. Shafer, G.N. Kotsonis, J-P. Maria, M. Trassin, R. Hovden, E. Kioupakis, J.T. Heron, Physical Review Materials, 3, 104420, 2019
  27. Quantification of Solute Topology in Atom Probe Tomography Data: Application to the Microstructure of a Proton-Irradiated Alloy 625, I. Ghamarian, L-J. Yu, E.A. Marquis, Metallurgical and Materials Transactions A, 1-9, 2019
  28. Wintertime Arctic Sea Spray Aerosol Composition Controlled by Sea Ice Lead Microbiology, R.M. Kirpes, D. Bonanno, N.W. May, M. Fraund, A.J. Barget, R.C. Moffet, A.P. Ault, K.A. Pratt, ACS Central Science, 2019 
  29. Isolation and Profiling of Circulating Tumor‐Associated Exosomes Using Extracellular Vesicular Lipid–Protein Binding Affinity Based Microfluidic Device, Y-T. Kang, E. Purcell, T-W. Lo, N. Ramnath, S. Jolly, S. Nagrath, Small, 1903600, 2019
  30. Emulation of Fast Reactor Irradiated T91 using Dual Ion Beam Irradiation, S. Taller, Z. Jiao, K. Field, G.S. Was, Journal of Nuclear Materials, 527, 151831, 2019 
  31. Diverse Nanoassemblies of Graphene Quantum Dots and Their Mineralogical Counterparts, N.A. Kotov, Z-b. Qu, W-J. Feng, Y. Wang, F. Romanenko, Angewandte Chemie, 58, 2-11, 2019 
  32. Oxide Growth and Dissolution on 316L Stainless Steel during Irradiation in High Temperature Water, R.D. Hanbury, G.S. Was, Corrosion Science, 157, 305-311, 2019
  33. Micro- and Nano-Scale Intermetallic Phases in AA2070-T8 and their Corrosion Behavior, Y. Zhu, K. Sun, J. Garves, L.G. Bland, J. Locke, J. Allison, G.S. Frankel, Electrochimica Acta, 319, 634-648, 2019 
  34. Annealing Induced Interfacial Evolution of Titanium/Gold Metallization on Unintentionally Doped β-Ga2O3, M. Lee, R.L. Peterson, ECS Journal of Solid State Science and Technology, 8(7), Q3176-Q3179, 2019
  35. Interfacial Reactions of Titanium/Gold Ohmic Contacts with Sn-Doped β-Ga2O3, M. Lee, R.L. Peterson, APL Materials, 7(2), 022524, 2019
  36. Kinetic Control on the Depth Distribution of Superdeep Diamonds, F. Zhu, J. Li, J. Liu, X. Lai, B. Chen, Y. Meng, Geophysical Research Letters, 46, 1984-1992, 2019
  37. Suppression of Shear Banding in High-Strength Cu/Mo Nanocomposites with Hierarchical Bicontinuous Intertwined Structures, Y. Cui, B. Derby, N. Li, N.A. Mara, A. Misra, Materials Research Letters, 6(3), 184-190, 2018
  38. Self-Ion Emulation of High Dose Neutron Irradiated Microstructure in Stainless Steels, Z. Jiao, J. Michalika, G.S. Was, Journal of Nuclear Materials, 501, 312-318, 2018
  39. Sensitization and Stress Corrosion Crack Response of Dual Certified Type 304/304L Stainless Steel, K.B. Fisher, B.D. Miller, R. Hermer, C. Brown, E.A. Marquis, Corrosion, 74(7), 737-746, 2018
  40. Charge Transfer and Collection in Dilute Organic Donor-Acceptor Heterojunction Blends, K. Ding, X. Liu, S.R. Forrest, Nano Letters, 18(5), 3180-3184, 2018
  41. Evolution of Local Lattice Distortion under Irradiation in Medium- and High-Entropy Alloys, Y. Tong, G. Velisa, S. Zhao, W. Guo, T. Yang, K. Jin, C. Lu, H. Bei, J.Y.P. Ko, D.C. Pagan, Y. Zhang, L. Wang, F.X. Wang, Materialia, 2, 73-81, 2018
  42. The Role of Surface Deformation in the Oxidation Response of Type 304 SS in High Temperature Deaerated Water, K.B. Fisher, B.D. Miller, E.C. Johns, E.A. Marquis, Corrosion Science, 141, 88-96, 2018
  43. Omnidispersible Hedgehog Particles with Multilayer Coatings for Multiplexed Biosensing, D.G. Montjoy, J.H. Bahng, A. Eskafi, H. Hou, N.A. Kotov, J. Am. Chem. Soc., 140(25), 7835-7845, 2018
  44. Early Oxidation Behavior of Si-Coated Titanium, K. Chou, P. Chu, E.A. Marquis, Corrosion Science, 140, 297-306, 2018
  45. Intergranular Li Metal Propagation through Polycrystalline Li6.25Al0.25La3Zr2O12 Ceramic Electrolyte, E.J. Cheng, A. Sharafi, J. Sakamoto, Electrochimica Acta, 85-91, 223, 2017
  46. High Thermal Conductivity in Electrostatically Engineered Amorphous Polymers, A. Shanker, C. Li, G. Kim, D. Gidley, K.P. Pipe, J. Kim, Science Advances, 3(7), 1700342, 2017
  47. The Effect of Ni:Co Ratio on the Elemental Phase Partitioning in γ-γ′ Ni-Co-Al-Ti-Cr Alloys, S.C.H. Llewelyn, K.A. Christofidou, V.J. Araullo-Peters, N.G. Jones, M.C. Hardy, E.A. Marquis, H.J. Stone, Acta Materialia, 131, 296-304, 2017
  48. Engineering the Optical and Catalytic Properties of Co-Catalyst/Semiconductor Photocatalysts, P.A. Hernley, S.A. Chavez, J.P. Quinn, S. Linic, ACS Photonics, 4(4), 979-985, 2017
  49. Adsorption of Aromatic Decomposition Products from Phenyl-Containing Magnesium-Ion Battery Electrolyte Solutions, A.J. Crowe, K.K. Stringham, J.L. DiMeglio, B.M. Bartlett, J. Phys. Chem. C, 121, 7711-7717, 2017
  50. Influence of a Silicon-Bearing Film on the Early Stage Oxidation of Pure Titanium, K. Chou, P.W. Chu, C.G. Levi, E.A. Marquis, Journal of Materials Science, 52(16), 9884-9894, 2017
  51. Microstructure of Localized Corrosion Front on Mg Alloys and the Relationship with Anodic Hydrogen Evolution, P.W. Chu, E. LeMire, E.A. Marquis, Corrosion Science, 128, 253-264, 2017
  52. Biomimetic Hierarchical Assembly of Helical Supraparticles from Chiral Nanoparticles, Y.L. Zhou, R.L. Marson, G. van Anders, J. Zhu, G. Ma, P. Ercius, K. Sun, B. Yeom, S.C. Glotzer, N.A. Kotov, ACS Nano, 10(3), 3248-3256, 2016
  53. Microstructure and Chemistry of Electrodeposited Mg Films. M.N. Bachhav, N.T. Hahn, K.R. Zavadil, E.G. Nelson, A.J. Crowe, B.M. Bartlett, P.W Chu, V.J. Araullo-Peters,  E.A. Marquis, Journal of The Electrochemical Society, 163(13), D1-D6, 2016
  54. Towards an Understanding of Tensile Deformation in Ti-based Bulk Metallic Glass Matrix Composites with BCC Dendrites, J. Kolodziejska, H. Kozachkov, K. Kranjc, A.H. Hunter, E.A. Marquis, K. Flores, W. Johnson, D. Hofmann, Scientific Reports, 6, 22563, 2016
  55. Macroporous p-GaP Photocathodes Prepared by Anodic Etching and Atomic Layer Deposition Doping, S. Lee, A.R. Bielinski, E. Fahrenkrug, N.P. Dasgupta, S. Maldonado, ACS Appl. Mater. Interfaces, 8(25), 16178-16185, 2016
  56. Lake Spray Aerosol: A Chemical Signature from Individual Ambient Particles, J.L. Axson, N.W. May, I.D. Colón-Bernal, K.A. Pratt, A.P. Ault, Environ. Sci. Technol., 50(18), 9835-9845, 2016